Safety Study of Purple Sweet Potatoes Leaves Extract (Ipomoea batatas (l.) Lamk) Antin-3 Variety as a Sunscreen Active Ingredient on Human Skin

D, Dipahayu and D, Arifiyana and M, Indramaya D and S, Anggraeni Safety Study of Purple Sweet Potatoes Leaves Extract (Ipomoea batatas (l.) Lamk) Antin-3 Variety as a Sunscreen Active Ingredient on Human Skin. International Journal of Drug Delivery Technology. ISSN ISSN: 0975 4415

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Abstract

Background: Ultraviolet (UV) radiation intensively has known as a major cause of photoaging and photodamage on skin. Anthocyanin is one of flavonoid group, which has a chromophore and conjugated double bond, absorbing electromagnetic radiation in UV wavelength. Ethanolic leaves extract of (Ipomoea batatas (L.) Lamk) Antin-3 variety contains considerably high anthocyanins so that it can be a potential sunscreen active ingredient. However, the safety effect of ethanolic extract of (Ipomoea batatas (L.) Lamk) Antin-3 variety on human skin is still unclear. Objective: The objective of this study is to evaluate the safety (irritation and allergic effect) of ethanolic leaves extract of (Ipomoea batatas (L.) Lamk) Antin-3 variety on human skin trough a patch test. Materials and Methods: Ethanolic young and old leaves extract of (Ipomoea batatas (L.) Lamk) Antin-3 variety. Each of them is on a 500, 1000 and 5000 ppm on vaselinum album base. The patch test was applied on the back skin on seven of adult females who are included in inclusion criteria (as a subject study) for 24 hours and they were observed for four days. Results: There are two out of seven subjects indicated irritation which understandably were caused by the old leaves 1000 and 5000 ppm. Conclusions: The old leaves vary in the phytochemical compound compared to the young leaves which have more potential risk to irritate and cause allergies to the human skin. Anthocyanin is a major content in young leaves. Keywords: Young leaves, old leaves, ethanolic leaves extract of Antin-3, skin irritation and allergy.

Item Type: Article
Subjects: Kesehatan > Farmasi > Teknologi Farmasi
Depositing User: Elvia Ikasari
Date Deposited: 17 Dec 2020 04:29
Last Modified: 31 Dec 2020 02:08
URI: http://repository.akfarsurabaya.ac.id/id/eprint/214

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